Fighting Against the Food Allergy Disease Burden
The Research Activity at the ImmunoNutritionLab is well focused on new effective strategies against Food Allergy. Food allergy is a growing health problem worldwide. Effective strategies are advocated to limit the disease burden. Human milk is considered a protective factor, but its mechanisms remain unclear. Butyrate is a gut microbiota-derived metabolite able to exert several immunomodulatory functions. The butyrate concentration in human milk is largely undefined. We are evaluating the butyrate concentration in human milk and their potential to exert a protective role against food allergy. The butyrate concentration in human milk is responsible for the modulatory effect on several tolerogenic mechanisms observed in all experimental models evaluated in the study. Many effects involve epigenetic mechanisms. The results of this research suggest the importance of butyrate as a pivotal human milk compound able to protect against food allergy.
In the midst of an emergency due to the epidemic caused by the new Coronavirus SARS-CoV-2, good news comes from the results of a study conducted at CEINGE-Biotecnologie advanced in Naples by the research team coordinated by Roberto Berni Canani.
The work, which will be presented at the next World Congress of Gastroenterology and Pediatric Nutrition in Copenhagen, demonstrates the efficacy of a functional food deriving from the fermentation of cow's milk with the probiotic L.paracasei CBA L74 in protecting human epithelial cells from infection by RNA viruses, such as the Coronavirus COVID-19. The researchers have indeed discovered that there is the possibility of inhibiting Rotavirus-induced infection, a genus of RNA viruses belonging to the Reoviridae family, which is the most important cause of acute pediatric gastroenteritis in the world.
"We have demonstrated - explains Berni Canani - the contemporary modulation of immunological and non-immunological protective mechanisms with consequent reduction of the inflammatory response and oxidative action produced by RNA viruses inside human cells".
Acute gastroenteritis is a very common cause of morbidity and mortality in children: it is estimated that a child under the age of 5 can present this infection up to 5 times in a year. According to the Global Health Data Exchange, acute gastroenteritis is the eighth leading cause of death in all ages (1.65 million deaths / year) and the fifth leading cause of death in children under the age of 5 (446,000 deaths / year). Up to 40% of these deaths are caused by Rotavirus infection.
"The results of our research confirm the potential importance of nutritional strategies based on functional foods for the prevention of viral infections", underlines prof. Berni Canani. «Considering that there are not many therapeutic strategies for RNA viruses, such as Coronavirus COVID-19, studies of this type are very useful to test the efficacy of new functional foods for protection against RNA viruses in humans».
"The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: a randomised, double-blind, placebo-controlled trial"
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